BDBM280339 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)pyrimidine-5-carboxamide::US10030004, Compound 4a::US10501436, Compound 4a::US11053216, Compound 4a::US11702401, Compound 4a

SMILES C[C@H](O)CNC(=O)c1cncnc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F

InChI Key InChIKey=GVDHTILDVBEBLW-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 280339   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.44E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 42.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Date in BDB:
8/18/2023
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/18/2023
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/18/2023
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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.44E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/18/2023
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMMore data for this Ligand-Target Pair

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Date in BDB:
2/6/2022
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 42.4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
2/6/2022
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.06E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.44E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 42.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 3.44E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 28.1nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 42.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280339((S)-4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.06E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL