BDBM280335 US10030004, Compound CE-1::US10501436, Compound CE-1::US11053216, Compound CE-1::US11702401, Compound CE-1

SMILES CC(O)CNC(=O)c1cnccc1Nc1nc(ccc1C(C)C)-c1cc(Cl)ccc1F

InChI Key InChIKey=ZKYAOTPTLLBEHA-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280335   

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/18/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

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TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

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TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280335(US10030004, Compound CE-1 | US10501436, Compound C...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL