BDBM27978 5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)thieno[2,3-d]pyrimidin-6-yl]ethynyl}pyrazin-2-amine::6-Ethynylthieno[2,3-d]pyrimidine, 13

SMILES Nc1cnc(cn1)C#Cc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)ncnc2s1

InChI Key InChIKey=WLEIXJUVTKOBDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 27978   

LigandPNGBDBM27978(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50: 372nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
LigandPNGBDBM27978(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50: 52nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
LigandPNGBDBM27978(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50: 1.35E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
LigandPNGBDBM27978(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50: 372nMAssay Description:Inhibition of EGFR (unknown origin) after 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed