BDBM279680 US10035797, Compound 17::US10428068, Compound 17::US10844056, Compound 17::US11560377, Compound 17::US9630965, Compound 17

SMILES COc1ccc(c(Sc2nc3c(N)nccc3n2CCCC#C)c1)[N+]([O-])=O

InChI Key InChIKey=VXQFVYTXUWTOGI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 279680   

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMpH: 7.3Assay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetHsp90 co-chaperone Cdc37(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetHsp90 co-chaperone Cdc37(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:HSP90: A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetHsp90 co-chaperone Cdc37(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Hsp90 chaperone assay was performed to measure the ability of HSP90 protein to refold the heat-denatured luciferase protein. HSP90 was first incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279680(US10035797, Compound 17 | US9630965, Compound 17 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent