BDBM279457 (R)-1-(5-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)-3-methylbutan-1-amine::US10035777, Example 8

SMILES CC(C)C[C@@H](N)c1nc2cc(ccc2[nH]1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=GWVLDODZZDWNGK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 279457   

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM279457(US10035777, Example 8 | (R)-1-(5-(7H-pyrrolo[2, 3-...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM279457(US10035777, Example 8 | (R)-1-(5-(7H-pyrrolo[2, 3-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of thrombin-recognition site-fused GST-tagged human AAK1 expressed in bacterial expression system using 5-FAM-Aha-KEEQSQITSQVTGQIGWR-NH2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed