BDBM27917 4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-1H-pyrrole-2-carboxamide::CHEMBL254702::arylamide, 8

SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1

InChI Key InChIKey=DXPSQKSTVIVZLV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 27917   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of Kit after 30 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TrkA after 27 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Flt3 after 25 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of Axl after 11 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM27917(CHEMBL254702 | 4-cyano-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed