BDBM279169 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-5-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 200::US10512632, Example 200::US10618913, Example S200::US10766893, Example S200::US10806718, Example 200::US11026923, Example 200::US11491140, Example 200::US11634416, Example 200

SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1ocnc1C

InChI Key InChIKey=JVGYDVFOXCBHRN-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 279169   

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 98nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 110nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent