BDBM27908 2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxycarbamoyl)-5-oxo-5H,8H-pyrido[2,3-d]pyrimidin-2-yl]amino}phenyl)piperidin-1-yl]acetic acid::Pyrido[2,3-d]pyrimidin-5-one, 36

SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O

InChI Key InChIKey=DZGGGZSDTNTLQN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 27908   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 2.20nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 41nMT: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 500nMT: 2°CAssay Description:Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor [440-796](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 500nMT: 2°CAssay Description:TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 13nMT: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27908(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Affinity DataIC50: 9.30E+3nMT: 2°CAssay Description:Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed