BDBM278968 5-Amino-3-[(2R,3R,5S)-5-(hydroxymethyl)-3-pyrrolidin-1-yl-tetrahydrofuran-2-yl]-6H-thiazolo[4,5-d]pyrimidine-2,7-dione::US10040815, Example 32::US10618929, Example 32

SMILES Nc1nc2n([C@@H]3O[C@H](CO)C[C@H]3N3CCCC3)c(=O)sc2c(=O)[nH]1

InChI Key InChIKey=GEVVIXVISDEXBL-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278968   

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM278968(5-Amino-3-[(2R,3R,5S)-5-(hydroxymethyl)-3-pyrrolid...)
Affinity DataEC50:  6.70E+4nMAssay Description:A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM278968(5-Amino-3-[(2R,3R,5S)-5-(hydroxymethyl)-3-pyrrolid...)
Affinity DataEC50:  6.70E+4nMAssay Description:A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat. #: hkb-ht1r7, San Diego, Calif., USA). These cells were designed for studyin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent