BDBM278964 5-amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxypropyl]-3-methyl-tetrahydrofuran-2-yl]-6H-thiazolo[4,5-d]pyrimidine-2,7-dione::US10040815, Example 28::US10618929, Example 28

SMILES CCC(O)[C@@H]1C[C@@H](C)[C@@H](O1)n1c2nc(N)[nH]c(=O)c2sc1=O

InChI Key InChIKey=PMUKMTXOKPUVCW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278964   

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM278964(5-amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxypropyl]-3-m...)
Affinity DataEC50:  1.00E+4nMAssay Description:A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat.#: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM278964(5-amino-3-[(2R,3R,5S)-5-[(1S)-1-hydroxypropyl]-3-m...)
Affinity DataEC50:  1.00E+4nMAssay Description:A stable HEK293-Blue-hTLR-7 cell line was purchased from InvivoGen (Cat. #: hkb-ht1r7, San Diego, Calif., USA). These cells were designed for studyin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent