BDBM278932 4-{8-amino-3- [(6S,8aR)-6-methyl-3- oxohexahydro[1,3] oxazolo[3,4-a] pyridin-6-yl] imidazo[1,5-a] pyrazin-1-yl}-3- ethoxy-N-[1-methyl- 5-(trifluoromethyl)- 1H-pyrazol-3- yl]benzamide::US10040805, Example 2

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)[C@@]1(C)CC[C@@H]2COC(=O)N2C1)C(=O)Nc1cc(n(C)n1)C(F)(F)F

InChI Key InChIKey=COCKMFCILCIFCN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278932   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278932(4-{8-amino-3- [(6S,8aR)-6-methyl-3- oxohexahydro[1...)
Affinity DataIC50: 3.07nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
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