BDBM27885 4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-[4-methyl-6-(1-methylpiperidin-4-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydropyridin-2-one::benzimidazole scaffold, 7

SMILES CN1CCC(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O

InChI Key InChIKey=QOTMLIIRYJJNCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27885   

TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM27885(4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-[4-...)
Affinity DataIC50: 26nMpH: 7.0 T: 2°CAssay Description:The IGF-1 receptor tyrosine kinase was assayed using the synthetic polymer poly(Glu/Tyr) as a phosphoacceptor substrate. Incorporated radioactivity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

LigandPNGBDBM27885(4-{[2-(4-chloro-1H-pyrazol-1-yl)ethyl]amino}-3-[4-...)
Affinity DataIC50: 4.00E+4nMpH: 7.4 T: 2°CAssay Description:The inhibition of recombinant human CYP3A4 was measured as the ability to perform a dealkylation of 7-benzyloxy-4-trifluoromethylcoumarin (BFC). Befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2009
Entry Details Article
PubMed