BDBM278822 2-[(1S,5R)- or (1R,5S)- 3,6- diazabicyclo[3.2.1]oct- 6-yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide::US10040798, Example 126

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C(F)F

InChI Key InChIKey=YDOCIUCUSWKRCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278822   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278822(2-[(1S,5R)- or (1R,5S)- 3,6- diazabicyclo[3.2.1]oc...)
Affinity DataIC50: 14nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent