BDBM278805 N-(2- cyanophenyl)-2- [(3R)-piperidin-3- ylamino]pyrrolo[1, 2-b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 105

SMILES O=C(Nc1ccccc1C#N)c1ccc2ccc(N[C@@H]3CCCNC3)nn12

InChI Key InChIKey=IHNRPDHHXXUTKL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278805   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278805(N-(2- cyanophenyl)-2- [(3R)-piperidin-3- ylamino]p...)
Affinity DataIC50: 6nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
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