BDBM278787 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-chlorothiophen- 3-yl)pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 85

SMILES N[C@H]1CCCC[C@H]1Nc1ccc2ccc(C(=O)Nc3cscc3Cl)n2n1

InChI Key InChIKey=AHGROYKEWKSINZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278787   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278787(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-chloro...)
Affinity DataIC50: 2nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
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