BDBM278741 2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oct- 2-yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 38

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C(F)F

InChI Key InChIKey=MEQMWGKXNYDXRF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278741   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278741(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Affinity DataIC50: 2nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent