BDBM278737 N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oct- 2-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 34

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Cl)n1

InChI Key InChIKey=LCLCNUDWWFNBRA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278737   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278737(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- [(1S,4S)...)
Affinity DataIC50: 15nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
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