BDBM278730 N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- (2,5- diazabicyclo[2.2.2]oct- 2-yl)pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 27

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(Br)n1

InChI Key InChIKey=NXXNHNIGLWXYQD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278730   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278730(N-(3-bromo-1-methyl- 1H-pyrazol-4-yl)-2- (2,5- dia...)
Affinity DataIC50: 24nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent