BDBM278711 2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide::US10040798, Example 11::US10040798, Example 8

SMILES Cn1cc(NC(=O)c2ccc3ccc(nn23)N2CC3CCC2CN3)c(n1)C(F)(F)F

InChI Key InChIKey=ODUGWVLZWFWUJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278711   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278711(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-...)
Affinity DataIC50: 19nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278711(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[1-methyl-...)
Affinity DataIC50: 27nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent