BDBM278615 (2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- methyloxetan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 77

SMILES CC1(CCO1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl

InChI Key InChIKey=ICORGZBJRVKPJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278615   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278615((2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- methylox...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM278615((2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- methylox...)
Affinity DataIC50: 94nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent