BDBM278515 US10040790, Example 31::US10450313, Example 31::US10947230, Example 31::US11530214, Example 31::methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridine]-6'-ylcarbamate

SMILES COC(=O)Nc1cc2c(CN(C(=O)C22CC2)c2c(F)c(OC)cc(OC)c2F)cn1

InChI Key InChIKey=XNPFFUMEQYIEGJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278515   

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278515(methyl 2'-(2,6-difluoro-3,5-dimethoxyphenyl)-3'-ox...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
US Patent