BDBM278500 7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-pyridin-3-yl-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one::US10040790, Example 16::US10450313, Example 16::US10947230, Example 16::US11530214, Example 16

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4cccnc4)c3N(C)C2=O)c1F

InChI Key InChIKey=DZMWVLAGFIMXPL-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278500   

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278500(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-met...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent