BDBM278499 7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-fluorophenyl)-1-methyl-3,4-dihydro-pyrido[4,3-d]pyrimidin-2(1H)-one::US10040790, Example 15::US10450313, Example 15::US10947230, Example 15::US11530214, Example 15

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccc(F)cc4)c3N(C)C2=O)c1F

InChI Key InChIKey=WSHPHXSKUFJZEO-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278499   

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM278499(7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(4-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent