BDBM278482 (2S)-2-(dimethylamino)-2-(4-methoxyphenyl)-N-::US10040789, Example 16

SMILES COc1ccc(cc1)[C@H](N(C)C)C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1

InChI Key InChIKey=DRCQRKLVRDOECS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278482   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278482((2S)-2-(dimethylamino)-2-(4-methoxyphenyl)-N- | US...)
Affinity DataIC50: 198nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278482((2S)-2-(dimethylamino)-2-(4-methoxyphenyl)-N- | US...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed