BDBM278480 (2R)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide::US10040789, Example 14

SMILES CN(C)[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1

InChI Key InChIKey=NBPVIHVBADJLHI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278480   

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278480((2R)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...)
Affinity DataIC50: 2.26E+3nMpH: 7.8 T: 2°CAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM278480((2R)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed