BDBM278286 5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methoxyphenyl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)benzonitrile::US10040781, Example 508::US10253019, Example 508

SMILES COc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCN(C[C@H]3F)C(=O)CO)c(c2)C#N)ccc1N1CCN(C)C[C@@H]1C

InChI Key InChIKey=RTNHWTLGYOUURJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 278286   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 2.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
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LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 4.90E+4nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 2nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM278286(5-(4-((4-((S)-2,4-dimethylpiperazin-1-yl)-3-methox...)
Affinity DataIC50: 49nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent