BDBM27791 2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4-yl)oxy]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluorobenzamide::pyrrolo[2,3-d]pyrimidine deriv., 9

SMILES CCCN1CCC(CC1)Oc1cc(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)c(OC)cc1Cl

InChI Key InChIKey=GGQTUXCKDZGJDL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 27791   

LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 25nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 3.98E+3nMAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
TargetRhodopsin kinase GRK1(Bovine)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 6.30E+3nMAssay Description:Displacement of BODIPY TR-ADP from human GRK2 preincubated for 10 mins followed by compound addition and measured after 10 to 15 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 3.20E+3nMAssay Description:Displacement of BODIPY TR-ADP from GRK5 (unknown origin) preincubated for 10 mins followed by compound addition and measured after 10 to 15 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRhodopsin kinase GRK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed