BDBM27783 2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide::BMCL19469 Compound 13::CHEMBL507625::pyrrolo[2,3-d]pyrimidine deriv., 1

SMILES COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C

InChI Key InChIKey=HXZDICYKFAOZLE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 27783   

LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Inhibitor binding to JNK3 was assessed by a fluorescence anisotropy competitive binding assay. The reaction mixture (JNK3 and fluorescently labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2009
Entry Details Article
PubMed
LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 117nMAssay Description:Inhibition of IGF1R phosphorylation by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
LigandPNGBDBM27783(CHEMBL507625 | BMCL19469 Compound 13 | 2-fluoro-6-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed