BDBM27781 N-[2-amino-5-(4-fluorophenyl)phenyl]-4-{1,8-diazaspiro[4.5]decan-8-ylcarbonyl}benzamide::terephthalamide, 29

SMILES Nc1ccc(cc1NC(=O)c1ccc(cc1)C(=O)N1CCC2(CCCN2)CC1)-c1ccc(F)cc1

InChI Key InChIKey=FUIWHQVIWYXEAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27781   

TargetHistone deacetylase 1(Human)
Merck Research Laboratories

LigandPNGBDBM27781(N-[2-amino-5-(4-fluorophenyl)phenyl]-4-{1,8-diazas...)
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Merck Research Laboratories

LigandPNGBDBM27781(N-[2-amino-5-(4-fluorophenyl)phenyl]-4-{1,8-diazas...)
Affinity DataIC50: 3.20E+3nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed