BDBM277789 5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile::US10040781, Example 11::US10253019, Example 11

SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncnc(n2)-c2ccc(OC3CCOCC3)c(c2)C#N)cc1

InChI Key InChIKey=RZSCALBGZVGSKD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 277789   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 1.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 4.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 2.24E+5nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 4nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM277789(5-(4-((4-(4-acetylpiperazin-1-yl)phenyl)amino)-1,3...)
Affinity DataIC50: 224nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent