BDBM27760 N-(2-hydroxy-5-phenylphenyl)-4-{[(pyridin-3-ylmethyl)amino]methyl}benzamide::US9096559, 81::aminophenol analogue, 8

SMILES Oc1ccc(cc1NC(=O)c1ccc(CNCc2cccnc2)cc1)-c1ccccc1

InChI Key InChIKey=JYIJWNFSCMYZSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27760   

TargetHistone deacetylase 1(Human)
Merck Research Laboratories

LigandPNGBDBM27760(N-(2-hydroxy-5-phenylphenyl)-4-{[(pyridin-3-ylmeth...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

LigandPNGBDBM27760(N-(2-hydroxy-5-phenylphenyl)-4-{[(pyridin-3-ylmeth...)
Affinity DataIC50: 32nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent