BDBM2775 Alkenyldiarylmethane (ADAM) 17a::Alkenyldiarylmethane (ADAM) 1b::Alkenyldiarylmethane (ADAM) 28c::Alkenyldiarylmethanes (ADAM) 17a::methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxycarbonyl)phenyl]-6-methoxy-6-oxohex-1-en-1-yl}-2-methoxybenzoate

SMILES [#6]-[#8]-[#6](=O)-[#6]-[#6]-[#6]\[#6]=[#6](/c1cc(Br)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6])-c1cc(Br)c(-[#8]-[#6])c(c1)-[#6](=O)-[#8]-[#6]

InChI Key InChIKey=TVTHRHIZDDSNDQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 2775   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 300nMpH: 7.9Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 1.00E+3nMpH: 7.9Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2005
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 300nMpH: 7.9Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 300nMpH: 7.9Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2004
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL
LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 300nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Purdue University

Curated by ChEMBL
LigandPNGBDBM2775(methyl 3-bromo-5-{1-[3-bromo-4-methoxy-5-(methoxyc...)
Affinity DataIC50: 300nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rC)-oligo)dG) as templateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed