BDBM277104 (S) or (R)-4-(4-chloro-2- fluorophenyl)-7-[(6,6- dimethyltetrahydro-2H- pyran-3-yl)methyl]- 5,6,7,8-tetrahydro-1,7- naphthyridine-2- carboxamide::US10072003, Example 1-21

SMILES CC1(C)CCC(CN2CCc3c(C2)nc(cc3-c2ccc(Cl)cc2F)C(N)=O)CO1

InChI Key InChIKey=ZUIFGAOTBIFOBN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 277104   

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277104(US10072003, Example 1-21 | (S) or (R)-4-(4-chloro-...)
Affinity DataIC50: 9.30E+3nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent