BDBM27709 2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-8-methyl-3,4-dihydroquinazolin-4-one::CHEMBL401843::quinazolinone analogue, 1e

SMILES Cc1cccc2c1N=C(NC2=O)CCC[N@@]3CCC(=CC3)c4ccc(cc4)F

InChI Key InChIKey=LOFDUAJQRUYHBR-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 27709   

TargetPoly [ADP-ribose] polymerase 1(Human)
Fujisawa Pharmaceutical

LigandPNGBDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 16nMpH: 8.0 T: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP enzyme assay was carried out in reaction mixture consisting of activated salmon teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Fujisawa Pharmaceutical

LigandPNGBDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 167nMT: 2°CAssay Description:To assess the inhibitory activity of novel inhibitors, the PARP enzyme assay was carried out in reaction mixture consisting of activated salmon teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Fujisawa Pharmaceutical

LigandPNGBDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Fujisawa Pharmaceutical

LigandPNGBDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Bovine)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 16nMAssay Description:Inhibition of calf thymus PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)