BDBM276750 (S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide::US10071992, Example 1::US10071992, Example 3.4::US11034678, Example 1::US11065249, WO2018033832-Ex.-1::US20250066337, Example 1::WO2018033832, Ex. 1
SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1
InChI Key InChIKey=UKBQFBRPXKGJPY-UHFFFAOYSA-N
Data 21 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 276750
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP1A2 in pooled human liver microsomes using acetaminophen as substrate incubated for 20 mins in presence of NADPH by HPLC-...More data for this Ligand-Target Pair
Affinity DataIC50: 17.2nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 μL of c...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of hERG by patch-clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 833nMAssay Description:Inhibition of rat DGAT2 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into tria...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2D6 in pooled human liver microsomes using dextrorphan as substrate incubated for 14 mins in presence of NADPH by HPLC-MS...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+4nMAssay Description:Reversible inhibition of CYP2C19 in pooled human liver microsomes using 4-Hydroxymephenytoin as substrate incubated for 20 mins in presence of NADPH ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Reversible inhibition of CYP2C9 in pooled human liver microsomes using 4-Hydroxydiclofenac as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2C8 in pooled human liver microsomes using desethylamodiaquine as substrate incubated for 10 mins in presence of NADPH by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP2B6 in pooled human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Reversible inhibition of CYP3A4/5 in pooled human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 17.2nMpH: 7.4 T: 2°CAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human DGAT1 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
TargetBeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT3 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into di...More data for this Ligand-Target Pair
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human MGAT2 using [1-14C]decanoyl-CoA and 1-decanoyl-rac-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacy...More data for this Ligand-Target Pair
TargetAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Mouse)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse MGAT1 using [1-14C]decanoyl-CoA and 2-oleoylglycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycer...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Affinity DataIC50: 17.2nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Affinity DataIC50: 181nMpH: 7.4 T: 2°CAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...More data for this Ligand-Target Pair