BDBM276746 US10071991, Compound (I-M7-2S,4R)::US11214566, Compound (I-M7-2S,4R)

SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(CO)C1

InChI Key InChIKey=YZMMABBFRTZKTK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276746   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetColony stimulating factor 1 receptor(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 6.60nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 6.60nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276746(US10071991, Compound (I-M7-2S,4R) | US11214566, Co...)
Affinity DataIC50: 7.90nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent