BDBM27660 4-Benzyl-2H-phthalazin-1-one::4-benzyl-1,2-dihydrophthalazin-1-one::4-benzylphthalazin-1(2H)-one::CHEMBL66761::US20230159469, Example 143::phthalazinone, 1

SMILES O=c1[nH]nc(Cc2ccccc2)c2ccccc12

InChI Key InChIKey=JUCCMEHWBGPJKS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 27660   

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 770nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 770nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ochanomizu University

Curated by ChEMBL
LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 5.37E+3nMAssay Description:Antagonist activity at wild type AR expressed in human SC cells assessed as inhibition of 1 nM DHT-induced cell proliferation after 3 days by WST-8 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 770nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 1.00E+4nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 770nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(CHEMBL66761 | 4-benzyl-1,2-dihydrophthalazin-1-one...)
Affinity DataIC50: 138nMAssay Description:Inhibition of C-terminal His-tagged human recombinant PARP-1 (1 to 1014 residues) expressed in Sf9 insect cells incubated for 1 hr by 32P-NAD+-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed