BDBM275999 US10071974, Example 110::US10071974, Example 111::US10577336, Example 111

SMILES Cc1cccn2c(ncc12)C(C)(NC(=O)[C@@H]1CNCCO1)C1CC1

InChI Key InChIKey=OPJHSVGAYVKGTA-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 275999   

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM275999(US10071974, Example 111 | US10071974, Example 110 ...)
Affinity DataEC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM275999(US10071974, Example 111 | US10071974, Example 110 ...)
Affinity DataEC50:  290nMpH: 7.4 T: 2°CAssay Description:Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM275999(US10071974, Example 111 | US10071974, Example 110 ...)
Affinity DataEC50:  1.00E+3nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM275999(US10071974, Example 111 | US10071974, Example 110 ...)
Affinity DataEC50:  290nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent