BDBM275891 US10071965, Compound PT191

SMILES CCc1ccc(Oc2ccccc2)c(=O)[nH]1

InChI Key InChIKey=HUALCBZXDKQHTJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275891   

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York

US Patent
LigandPNGBDBM275891(US10071965, Compound PT191)
Affinity DataKi:  196nM ΔG°:  -9.14kcal/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York

US Patent
LigandPNGBDBM275891(US10071965, Compound PT191)
Affinity DataKi:  729nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent