BDBM275416 1-[(1S)-1-(4-fluorophenyl)-2-hydroxy-2- methylpropyl]-3-[1-(4-fluorophenyl)-1H- pyrazolo[3,4-c]pyridin-5-yl]urea::US9884048, Example 295

SMILES CC(C)(O)[C@@H](NC(=O)Nc1cc2cnn(-c3ccc(F)cc3)c2cn1)c1ccc(F)cc1

InChI Key InChIKey=SRHJAEKGHXCUTC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275416   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275416(1-[(1S)-1-(4-fluorophenyl)-2-hydroxy-2- methylprop...)
Affinity DataIC50: 1.29nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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