BDBM275413 (S)-1-(2-methyl-2-hydroxy-1-phenylpropyl)-3-(1-(2-methylpyridin-4-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)urea::US9884048, Example 292

SMILES Cc1cc(ccn1)-n1ncc2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12

InChI Key InChIKey=FSHMFBKHYDYXMZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275413   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275413((S)-1-(2-methyl-2-hydroxy-1-phenylpropyl)-3-(1-(2-...)
Affinity DataIC50: 0.560nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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