BDBM275314 1-[1-(4-fluorophenyl)-1H- pyrazolo[3,4-c]pyridin-5-yl]-3- [(3R,4S)-1-methyl-4- phenylpyrrolidin-3-yl]urea::US9884048, Example 208

SMILES CN1C[C@H](NC(=O)Nc2cc3cnn(-c4ccc(F)cc4)c3cn2)[C@H](C1)c1ccccc1

InChI Key InChIKey=GFRXZFXYBSCKFM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275314   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275314(1-[1-(4-fluorophenyl)-1H- pyrazolo[3,4-c]pyridin-5...)
Affinity DataIC50: 0.580nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent