BDBM275313 1-[(1S)-2-hydroxy-2-methyl-1- phenylpropyl]-3[-1-(2-methyl- 2H-indazol-5-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl]urea::US9884048, Example 207

SMILES Cn1cc2cc(ccc2n1)-n1ncc2cc(NC(=O)N[C@@H](c3ccccc3)C(C)(C)O)ncc12

InChI Key InChIKey=BBAJXJDWPSNYDW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275313   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275313(1-[(1S)-2-hydroxy-2-methyl-1- phenylpropyl]-3[-1-(...)
Affinity DataIC50: 0.330nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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