BDBM275221 1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3- yl]-3-[1-(2-methylpyridin-4- yl)-1H-pyrazolo[3,4-c]- pyridin-5-yl)urea::US9884048, Example 115::US9884048, Example 185

SMILES CN1C[C@H](CCc2ccccc2)[C@H](C1)NC(=O)Nc1cc2cnn(-c3ccnc(C)c3)c2cn1

InChI Key InChIKey=DUGOFIFOYMMTMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275221   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275221(1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3...)
Affinity DataIC50: 0.690nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275221(1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3...)
Affinity DataIC50: 0.180nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent