BDBM275220 1-[(5-methyl-3-phenyl- isoxazol-4-yl)methyl]-3-[1- (2-methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl)urea::US9884048, Example 114

SMILES Cc1onc(c1CNC(=O)Nc1cc2cnn(-c3ccnc(C)c3)c2cn1)-c1ccccc1

InChI Key InChIKey=KHTBRYCNJQPQKA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275220   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275220(1-[(5-methyl-3-phenyl- isoxazol-4-yl)methyl]-3-[1-...)
Affinity DataIC50: 2.14nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
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Date in BDB:
12/12/2018
Entry Details
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