BDBM275207 1-[(2S,3S,4R)-1,2-dimethyl- 4-(2-methylphenyl)- pyrrolidin-3-yl]-3-[1-(2- methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl)urea::US9884048, Example 101

SMILES C[C@H]1[C@@H](NC(=O)Nc2cc3cnn(-c4ccnc(C)c4)c3cn2)[C@@H](CN1C)c1ccccc1C

InChI Key InChIKey=ZCEWBWKPNNOVDB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275207   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275207(1-[(2S,3S,4R)-1,2-dimethyl- 4-(2-methylphenyl)- py...)
Affinity DataIC50: 0.5nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
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