BDBM275171 1-[(1S)-2-hydroxy-1- phenylethyl]-3-[1-(2- methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl]urea::US9884048, Example 65

SMILES Cc1cc(ccn1)-n1ncc2cc(NC(=O)N[C@H](CO)c3ccccc3)ncc12

InChI Key InChIKey=IBIQMNFNRYUHBN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275171   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275171(1-[(1S)-2-hydroxy-1- phenylethyl]-3-[1-(2- methylp...)
Affinity DataIC50: 1.02nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent