BDBM275163 1-(1-methyl-4- phenylpyrrolidin-3-yl)-3-[1- (2-methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl]urea::US9884048, Example 57

SMILES CN1CC(NC(=O)Nc2cc3cnn(-c4ccnc(C)c4)c3cn2)C(C1)c1ccccc1

InChI Key InChIKey=XGZZIQXUNIFRHE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275163   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275163(1-(1-methyl-4- phenylpyrrolidin-3-yl)-3-[1- (2-met...)
Affinity DataIC50: 0.820nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent