BDBM275043 N2-(tert-butyl)-N8-((3-(pyridin-2-yl)isoxazol- 5-yl)methyl)-5-(3- (trifluoromethoxy)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide::US9877957, Example 80

SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cc(no1)-c1ccccn1

InChI Key InChIKey=DTXWBWXXOPTGMZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275043   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275043(N2-(tert-butyl)-N8-((3-(pyridin-2-yl)isoxazol- 5-y...)
Affinity DataIC50: 524nMpH: 7.0 T: 2°CAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent