BDBM2727 3-[2-(2-chloro-6-fluoro-3-hydroxyphenyl)cyclopropyl]-1-(5-chloropyridin-2-yl)urea::N-[cis-2-(2-Chloro-6-fluoro-3-hydroxyphenyl)cyclopropyl]-N-[2-(5-chloropyridyl)]urea::urea-PETT deriv. 12

SMILES Oc1ccc(F)c(C2CC2NC(=O)Nc2ccc(Cl)cn2)c1Cl

InChI Key InChIKey=NTNATEYJPONKDY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2727   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2727(N-[cis-2-(2-Chloro-6-fluoro-3-hydroxyphenyl)cyclop...)
Affinity DataIC50: 135nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2727(N-[cis-2-(2-Chloro-6-fluoro-3-hydroxyphenyl)cyclop...)
Affinity DataIC50: 4.30E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Medivir

LigandPNGBDBM2727(N-[cis-2-(2-Chloro-6-fluoro-3-hydroxyphenyl)cyclop...)
Affinity DataIC50: 2.70E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2004
Entry Details Article
PubMed